![]() ![]() The highly porous three-dimensional (3D) structure of electrospun fibrous scaffolds can facilitate the exchange of cellular nutrients and create an ideal cellular micro-environment for wound healing. In addition, the electrospun nanofiber scaffolds have high porosity and high specific surface area, which are conducive to absorbing wound exudate and preventing the invasion of bacteria from the external environment. During the past few decades, the development of electrospun fibrous scaffolds as wound dressings or matrices has been introduced as alternatives to traditional wound care products because of the simple electrospinning process, which does not require expensive or complex fabrication instruments, and the scaffolds porous structure similar to the human native extracellular matrix (ECM). Due to their vital functions as a physical, chemical, and bacterial barrier, the selection of skin wound-healing agents or dressings plays an important role in tissue restoration, prevention of dermal or systemic infections, and ultimately in the aesthetic outcome of wound healing. However, skin injuries, including burns, diabetic ulcers, and other accidents, are considerable challenges in dermatology and skin care. Skin is the largest organ in the human body and provides us from external aggressions and pathogens. This new electrospun fibrous scaffolds with wound-healing promotion and antibacterial property should be convenient for treating wound healing. The resultant PCL-Col/ZnO fibrous scaffolds containing vascular endothelial growth factor (VEGF) also exhibited promoted wound-healing effect through promoting expression of transforming growth factor-β (TGF-β) and the vascular factor (CD31) in tissues in the early stages of wound healing. Moreover, the PCL-Col/ZnO fibrous scaffolds showed excellent cytocompatibility for promoting cell proliferation. ![]() The as-fabricated PCL-Col/ZnO fibrous scaffolds exhibited good swelling, antibacterial activity, and biodegradation behaviors, which were beneficial for the applications as a wound dressing. In this work, the antibacterial ZnO quantum dots (ZnO QDs) have been incorporated into the biocompatible poly (ε-caprolactone)/collagen (PCL/Col) fibrous scaffolds for wound healing. ![]() Nanofibers (NFs) have been widely used in tissue engineering such as wound healing. ![]()
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